To determine the role of EHD1 in NSCLC development, we analysed EHD1 expression in squamous cell lung carcinoma samples, lung adenocarcinoma samples and para-carcinoma normal lung tissues obtained from The Cancer Genome Atlas (TCGA) database and found that EHD1 expression were dramatically upregulated in both adenocarcinomas and squamous cell carcinomas compared with the non-malignant samples (P < 0.01, Fig. 6a). This evidence concerns the gene EHD1 and lung adenocarcinoma.