Moreover, the expression of FAK, IGF1R, EGFR, and YY1 was markedly increased in CRC cells (HCT116 and HT29) co-transfected with miR-7 mimics and circHIPK3 vectors compared with the cells transfected with miR-7 mimics alone (Fig. 5g). This evidence concerns the gene IGF1R and colorectal carcinoma.