NPPB and cardiac hypertrophy: Our study suggested that SFI attenuated myocardial hypertrophy probably by enhancing the expression of miR-19a-3p and down-regulating the expression of MEF2A, β-MHC, BNP and TRPC1, which seemingly implies that the SFI mediated improvement within MEF2 signaling might be the cause of attenuated myocardial hypertrophy.