Therefore, in the VAT, the potential involvement of the elevated immune cells (i.e. CD45+ leukocytes and CD11c+ M1 macrophages) in the development of AT inflammation and IR in obese humans is likely, indicated by a strong positive correlation between these CD45+ leukocytes and HOMA-IR (r = 0.514; p = 0.001) and a tendency for a positive correlation between CD8+ cytotoxic T-cells and HOMA-IR (r = 0.290; p = 0.069) (Table 3). The gene discussed is ITGAX; the disease is ataxia telangiectasia.