Since recent studies have modified the CSDS protocol to successfully induce depression-like behavior in female C57BL/6J mice40,41, future studies can take advantage of this paradigm to further explore these sex differences and determine whether, similar to males, the transcriptional activation induced by ERα in the female NAc recapitulates the transcriptional profile of female resilience. This evidence concerns the gene ESR1 and depressive symptom measurement.