Compared to the non-DKD patients, those with DKD were older with a prolonged duration of diabetes, higher prevalence of hypertension, higher ARB or ACEI medication, higher use of insulin, higher WHtR, SBP, DBP, HbA1c, FPG, TG and lower Hemoglobin (HGB) (all P < 0.05). This evidence concerns the gene INS and diabetes mellitus.