The CD4+ T-cell compartment of Cnb1CD11c mice was also normal: T helper cells (both naïve and memory) and Treg cells expressed normal calcineurin B levels, were able to produce effector cytokines (including IL-2, IFNγ, and IL-10) at normal levels, and naïve T helper cells isolated from these mice were able to induce severe colitis when adoptively transferred into lymphopenic mice. This evidence concerns the gene IL10 and colitis.