The difference between Il2CD4 and Il2CD11c is even more striking in the intestine, where loss of myeloid IL-2 resulted in a higher exacerbation of spontaneous colitis and a higher increase in the total number of leukocytes and activated CD4+ T effector cells producing IFNγ and IL-17 compared to mice lacking T-cell-produced IL-2. This evidence concerns the gene IFNG and colitis.