The quantification revealed that Dox-treatment of age-matched ApcMin/+Plk1iKD mice did not change the number of polyps in the large intestine, but increased significantly the number of adenomas in small intestines (4.23 ± 0.3) compared to mice without Dox-treatment (2.2 ± 0.2) having normal levels of Plk1 (Fig. 8d, left panel). The gene discussed is PLK1; the disease is adenoma.