APC and cervical squamous intraepithelial neoplasia: While the expression of APC-ΔC in CIN HCT116 cells for 24 h led to an increase of the percentage of polyploid cells from 3 to 8%, the BI6727-treatment and APC-ΔC-expression of HCT116 cells induced an increase from 7 to 12% (P < 0.05; Fig. 3a). The same treatment in CIN+ SW480 cells induced an increase from 9 to 15% and from 11 to 20% in APC-ΔC-expressing SW480 cells, respectively (P < 0.01; Fig. 3a).