PLK1 and adenoma: In the parallel experiment using for the inhibition of Plk1 the oral application of BI6727 in ApcMin/+ mice, the treatment with BI6727 did not change the low number of adenomas/mouse in the large intestine (0.33 ± 0.1), but a significant increase was observed for the number of adenomas in the small intestine from 2.63 ± 0.2 per control mouse to 7.77 ± 0.3 in BI6727-treated animals representing an increase of 295% (Fig. 8d, right panel).