BECN1 and ovarian carcinoma: Studies using ovarian cancer cell lines have also found that the levels of autophagy were significantly higher in A2780cp cells (cisplatin-resistant ovarian carcinoma cells) than in A2780 cells (parental cell line) and that inhibition of autophagy by siRNA knockdown of Beclin-1 expression enhanced cisplatin-induced cell death and apoptosis20.