The second study by Rico et al.38 found an increase in the protein abundance of mTOR and its downstream effectors—RPS6KB1 (ribosomal protein S6 kinase B1), RPS6 (ribosomal protein S6), eIF4B (eukaryotic translation initiation factor 4B) and PPARG (peroxisome proliferator-activated receptor gamma)—in three human granulosa cell tumors samples relative to normal granulosa cells. This evidence concerns the gene RPS6KB1 and granulosa cell tumor.