In addition, we performed gene set enrichment analysis (GSEA) in TCGA and confirmed that genes comprising the TGF-β program signature and the cell adhesion program signature, two programs widely accepted for their cancer metastasis regulation role, were both highly enriched for ovarian cancer samples with differential SORBS2 expression levels (Fig. 1e), further corroborating the regulatory role of SORBS2 in ovarian cancer metastasis. This evidence concerns the gene TGFB1 and cancer.