Among all these RBP genes, only four showed deletion in more than 5% of TCGA ovarian cancer samples, including transcription factor BTF3, sorbin and SH3 domain-containing protein 2 (SORBS2), cold-inducible RNA-binding protein (CIRBP), and RNA-binding protein MEX3D (MEX3D) (Fig. 1b). The gene discussed is BTF3; the disease is ovarian carcinoma.