Corresponding with a decisive role for SORBS2-stablized WFDC1 and IL-17D in generating a metastasis-suppressing phenotype of ovarian cancer, the expression levels of 8 and 14 M2 markers and cytokines also showed significant negative correlation with combined SORBS2/WFDC1 (Fig. 7d) and SORBS2/IL-17D levels (Fig. 7e), respectively, constituting a tumor-suppressive immune microenvironment. This evidence concerns the gene IL17D and ovarian cancer.