We analyzed the mRNA levels of fourteen significantly differentially secreted proteins: OMD, periostin, IGF2, IGFBP5, calumenin and VCAM1 for the lowered and fibulin-3, SERPIN E1 and E2, IGFBP6, SH3BGRL3, alpha-2-HS-glycoprotein, CHI3L1 and CSF1, for the increased. This evidence concerns the gene EFEMP1 and occult macular dystrophy.