CXCL8 and type 2 diabetes mellitus: One study found that under both spontaneous and lipopolysaccharide-stimulated conditions, neutrophils from type 2 diabetic patients produced higher amounts of the cytokines interleukin-8 (IL-8), interleukin -1β (IL-1β), TNFα and interleukin-1 receptor antagonist (IL-1RA) compared to healthy controls [38].