It seems from our results that ABPA patients carrying the disease associated EEA1 alleles have significantly increased phagocytosis and phagolysosome acidification, and further functional and mechanistic experimentation, which were outside the remit of this initial study, will be useful to elucidate a mechanism for how the mutations result in this increased phagocytosis, and why this is detrimental in ABPA. The gene discussed is EEA1; the disease is allergic bronchopulmonary aspergillosis.