In the present study, we transplanted mouse mammary tumor cells onto the cranial bone and into a subcutaneous lesion in mice, and then treated the mice with recombinant human TNFRSF11B: In this study, we refer to recombinant human TNFRSF11B as hOCIF and endogenouse mouse TNFRSF11B as mouse osteoprotegrin (mOPG). The gene discussed is TNFRSF11B; the disease is breast cancer.