Previously, we demonstrated that matrix metalloproteinase 7 (MMP7) could cleave membrane-bound RANKL into a soluble form (sRANKL), which abate the contact-dependent nature of osteoblast-osteoclast interaction and promote osteoclast activation and subsequent osteolysis in a prostate cancer model [9]. The gene discussed is MMP7; the disease is Familial prostate cancer.