SPIN1 expression in cells is tightly controlled, as several studies have shown that SPIN1 expression could be negatively monitored by some tumor suppressive non-coding RNAs, such as miR-489 and miR-219–5p (Chen et al., 2017; Drago-Ferrante et al., 2017; Li et al., 2017). The gene discussed is SPIN1; the disease is neoplasm.