CGAS and Aicardi-Goutieres syndrome: The cGAS-MITA pathway is critically essential in host immune defense against incoming pathogens, however, aberrant activation of the cGAS-MITA pathway can also lead to autoimmune and inflammatory disease, such as Aicardi Goutieres syndrome (AGS) and STING-associated vasculopathy with onset in infancy (SAVI) (Chen et al. 2016b; Gao et al. 2015; Liu et al. 2014; Pokatayev et al. 2016).