HAVCR2 and Miyoshi myopathy: T cell Immunoglobulin Mucin-3 (TIM-3) is another T cell receptor often expressed on TILs in conjunction with PD-1, which, like PD-1 and LAG-3, also serves as a negative T cell regulator and thus a potential therapeutic target in MM, alone or in conjunction with anti-PD-1 therapy [62].