TP53 and colorectal carcinoma: In a study evaluating a mutant p53-exposed PBMC-based vaccine in 24 patients with malignant p53-mutated tumors (including 10 CRC patients), 45% (9/20) of evaluable patients experienced a detectable cellular immune response and PFS and OS were greater than expected (12.5 and 27.2 months, respectively) [126].