KRAS and pancreatic adenocarcinoma: In a phase I/II clinical trial, an intradermal combination of KRAS mutant-derived synthetic peptides and GM-CSF administered to 48 pancreatic adenocarcinoma patients showed a peptide-specific immune response in 58% (25/43) of evaluable patients, and a prolonged median OS in this subset compared to immune non-responders (148 vs. 61 days, p = 0.0002) [106].