CTLA4 and gastric cancer: Other active avenues of research include comparing anti-CTLA-4 therapy to supportive standard of care following first-line chemo in patients with unresectable locally advanced or metastatic gastric and gastroesophageal junction malignancy (phase II, NCT01585987), and evaluating anti-PD-1 therapy with or without anti-CTLA-4 blockade in multiple solid tumors, including gastric cancer (phase I/II, NCT01928394).