BRAF and Miyoshi myopathy: Attempts to block Programmed Death Ligands with mAbs (BMS-936559 and MPDL3280A) have not yielded results as promising as PD-1 blockade in MM [58], though phase I trials are currently investigating their efficacy in combination with BRAF inhibitors (NCT01656642) and IFN-α (NCT02174172).