CD274 and gastric cancer: In an ongoing phase I trial, anti-PD-1 therapy with pembrolizumab (10 mg/kg q2W up to 24 mo) in PD-L1 expressing gastric cancer (n = 39) with median 6 mo follow-up has so far yielded an ORR of 30–32%, and a median response duration has not yet been reached (range 2–5 mo, NCT01848834) [90].