“Self” antigens have included Carcinoembryonic Antigen (CEA), for which the presence of corresponding autoantibodies in CRC patients correlates with better prognosis and increased 2-year survival rates [121], Epithelial Cell-Adhesion Molecule (Ep-CAM), and mucin glycoprotein MUC1, among others, all of which are overexpressed by subsets of CRC tumor cells. The gene discussed is CEACAM5; the disease is colorectal carcinoma.