Future potential targets in gastric cancer include T regs, myeloid-derived suppressor cells (MDSCs), and bone-marrow derived mesenchymal stem cells (BM-MSCs), all of which have been shown to promote an immunosuppressive environment in the setting of gastric cancer, as well as secreted immunosuppresive molecules (e.g. TGF-b, IL-10) that are associated with reduced survival in this disease [95]–[97]. This evidence concerns the gene TGFB1 and gastric cancer.