CXCL8 and nevus comedonicus syndrome: As expected, IL-8, the main chemoattractive for neutrophils, has been observed in NC [124] in keratinocytes from skin lesions of psoriasis vulgaris and generalized pustular psoriasis [125] and in synovial lesions of PsA [126], suggesting a key role in the pathogenesis of NC among patients with psoriasis.