SPI1 and leukemia: Regulating gene expression↑monocytic (leukemia) cell differentiation, Proliferation inhibition,↑ demethylation of a specific CpG site in interon 1 on H-Ras gene,↑H-Ras isoform mRNA and protein expression↑active phosphorylated forms of C/EBPβ and ERK1/2,↑proteins expression of CCAAT/enhancer-binding proteins (C/EBP and C/EBP), PU.1, and c-Jun (myeloid lineage-specific transcription factors)→ ↑expression of M-CSF recepror