On the other hand, the SPINT2 gene was initially identified as a gene overexpressed in pancreatic cancer under the name of Kop (Kunitz domain containing protein overexpressed in pancreatic cancer) [29], and HAI-2 protein was initially discovered in and purified from culture supernatant of a gastric carcinoma cell line [2]. Here, SPINT2 is linked to gastric carcinoma.