In HAI-2-low types of cancer, downregulation of HAI-2 was mediated by promoter hypermethylation of the SPINT2 gene [30–32], and recently, SPINT2 hypermethylation was reported in other cancer types, such as esophageal carcinoma and gastric cancer [51, 52]. The gene discussed is SPINT1; the disease is carcinoma of esophagus.