As shown in Figure 2, the Brd4 inhibitor JQ1 markedly reduced the mRNA expression levels of Atg3, Atg7, and CEBPβ in the OCI-AML3 NPMc+ cell line (Figure 2A), as well as in primary NPMc+ AML (Figure 2C, 2D, 2E, 2F, and Supplementary Table 1), and ML2 MLL cells (Figure 2B). The gene discussed is RUNX2; the disease is acute myeloid leukemia.