On Kaplan–Meier analysis, we found that patients whose tumours harboured Ki67 proliferation rate at 14% and greater disclosed both poorer DFS (p=0.008 and p=0.005) and OS (p=0.006 and p=0.007) (Figure 2 and 3) in the whole series and ER positive series respectively. This evidence concerns the gene MKI67 and neoplasm.