MKI67 and neoplasm: On multivariate analysis (adjusted for age, tumour size, histologic grade and axillary lymph node status), tumours with high proliferation rate (Ki67 ≥14%) and tumours which harboured high proliferation rate accompanied by PR<20%, had increased likelihood of recurrences (HR 1.941, 95%CI 1.105-3.408, p=0.021), (HR 2.069, 95%CI 1.168-3.667, p=0.013) and shorter OS (HR 2.201, 95%CI 1.159-4.180, p=0.016), (HR 2.491, 95%CI 1.309-4.740, p=0.005) respectively in the whole series (Table 6).