BRCA1 and familial pancreatic carcinoma: Human pancreatic cancer cells lines (BxPC-3, CFPAC-1) were exposed to 0.5μM pimasertib under hypoxia (3% 02) for 4 hours and downregulation of BRCA2 protein expression was observed upon MEK inhibition (Figure 1A) whereas BRCA1 expression was unaffected (data not shown).