There was significant increased apoptosis in pancreatic cancer cell lines in which the MEK inhibitor caused inhibition of BRCA2 expression and enhanced antitumor activity in BRCA2 wild-type pancreatic xenograft tumors treated with evofosfamide plus pimasertib, compared with cancers treated with evofosfamide alone. The gene discussed is BRCA2; the disease is familial pancreatic carcinoma.