MBD4 and colorectal carcinoma: Our data indicates that TAS-102-based therapy is effective not only for patients with 5-FU-refractory CRC, but also for stage II CRC patients with MSI-H tumors who do not benefit from 5-FU-based adjuvant therapy or 5-FU-treatment-naive patients with MSI-H/MBD4 frameshift mutant CRC.