[22, 23, 33, 34] In an experiment, Bader et al. demonstrated that the expression of truncated MBD4 in MSI CRC cell lines increased the mutation frequency during cancer progression, [33] and Abdel-Rahman et al. demonstrated that human CRC cell lines with truncated MBD4 expression are sensitive to cisplatin, which damages the DNA by causing intrastrand G-G adducts, but are resistant to etoposide which inhibits topoisomerase II. This evidence concerns the gene MBD4 and cancer.