Compared with CD10-negative MCL, CD10+ MCL more often had a diffuse growth pattern [56% (9/16) vs 28% (35/124), p = 0.04], blastoid/pleomorphic morphology [60% (18/30) vs 20% (43/212), p < 0.0001], and showed BCL6 expression [31% (6/19) vs 7% (5/72), p = 0.009]. This evidence concerns the gene BCL6 and mantle cell lymphoma.