The results of the present meta-analysis showed a clear relation of the polymorphism with disease in this subdivision in the dominant, recessive and homozygous models, correlated with several studies exploring the role of MIF in homeostasis and inflammation, and since the pathogenesis of most age-related diseases led to a special type of chronic inflammation, the so called “inflammaging,” is therefore not surprising that we observed an association of the MIF polymorphism with these diseases (Harper et al., 2010; Palumbo et al., 2013; Sauler et al., 2015; Xu et al., 2016). Here, MIF is linked to inflammatory response.