GNAS and pseudohypoparathyroidism: Between 3 and 9 CpG sites are affected in Beckwith-Wiedemann syndrome (the lowest p = 1.01 × 10−19) and transient neonatal diabetes (4.38 × 10−71) patients, respectively, compared with matched control subjects (Docherty et al., 2014), while two encompassing CpG sites are impacted in pseudohypoparathyroidism patients with GNAS cluster imprinting defects (Rochtus et al., 2016).