GNAS and Beckwith-Wiedemann syndrome: We observed that the PARD6G-AS1 DMR domain is hypomethylated in three imprinted diseases—Beckwith-Wiedemann syndrome, transient neonatal diabetes (Docherty et al., 2014), and pseudohypoparathyroidism in patients with GNAS cluster imprinting defects (Rochtus et al., 2016)—compared with matched control subjects (Figure 6A).