We observed that the PARD6G-AS1 DMR domain is hypomethylated in three imprinted diseases—Beckwith-Wiedemann syndrome, transient neonatal diabetes (Docherty et al., 2014), and pseudohypoparathyroidism in patients with GNAS cluster imprinting defects (Rochtus et al., 2016)—compared with matched control subjects (Figure 6A). This evidence concerns the gene PARD6G and pseudohypoparathyroidism type 1A.