We observed that the PARD6G-AS1 DMR domain is hypomethylated in three imprinted diseases—Beckwith-Wiedemann syndrome, transient neonatal diabetes (Docherty et al., 2014), and pseudohypoparathyroidism in patients with GNAS cluster imprinting defects (Rochtus et al., 2016)—compared with matched control subjects (Figure 6A). The gene discussed is GNAS; the disease is pseudohypoparathyroidism type 1A.