Between 3 and 9 CpG sites are affected in Beckwith-Wiedemann syndrome (the lowest p = 1.01 × 10−19) and transient neonatal diabetes (4.38 × 10−71) patients, respectively, compared with matched control subjects (Docherty et al., 2014), while two encompassing CpG sites are impacted in pseudohypoparathyroidism patients with GNAS cluster imprinting defects (Rochtus et al., 2016). This evidence concerns the gene GNAS and Beckwith-Wiedemann syndrome.