A pioneer study has shown, in a transgenic mouse model in which FAP-expressing cells can be ablated, that the depletion of FAP-expressing cells cause rapid hypoxic necrosis of both Lewis lung carcinoma and stromal cells in immunogenic tumors by a process involving IFN-γ and TNF-α, which have previously been shown to be involved in CD8+ T cell-dependent killing of tumor cells (188). The gene discussed is CD8A; the disease is neoplasm.