MICA and melanoma: We also recently demonstrated that CAFs isolated from melanoma decrease the susceptibility of melanoma tumor cells to NK cell-mediated lysis through the secretion of active MMPs which cleave two ligands of the NK-activating receptor NKG2D, MHC class I-related chain (MIC)-A and MIC-B, at the surface of the tumor cells and consequently decrease the NKG2D-dependent cytotoxic activity of NK cells against melanoma tumor cells, as well as their secretion of IFN-γ (102).