In the TME, the presence of CAFs and their secretion of CCL2, CCL5, and CCL17 as well as the polarizing cytokines IL-1, IL-6, IL-13, and IL-26 can favor a tumor promoting TH2 and TH17 immune response, as the expense of tumor protective TH1 response (32, 137–139). Here, IL1B is linked to neoplasm.