For example, trihydroxyphenolic compounds were identified as potent blockers of TGF-β1 in the presence of active lysyl oxidase-like 2 (LOXL2; a member of mammalian copper-dependent LOX enzymes only expressed by fibroblasts or cancer cells and involved in intra- and intermolecular covalent collagen cross-links), and induce potent blockade of pathological collagen accumulation in vivo (196). The gene discussed is LOXL2; the disease is cancer.