Similarly, in LL2 (murine lung cancer), CT26 (murine colon cancer), and B16F10 (murine melanoma) models, a whole-tumor cell vaccine modified to express FAP seems to induce antitumor immunity against both tumor cells and CAFs and enhances the infiltration of CD8+ T lymphocytes and decreases the accumulation of immunosuppressive cells in the TME (194). This evidence concerns the gene CD8A and melanoma.