CHI3L1 and cancer: It was also recently shown that Chitinase-3-like-1 (Chi3L1; YKL-40 in humans), a secreted glycoprotein involved in several diseases including chronic inflammatory conditions, fibrotic disorders and various types of cancer, is highly expressed in CAFs isolated from mammary tumors and pulmonary metastases in mice, and in the stromal compartment of human breast carcinomas, and enhances macrophage migration in the TME and their expression of an M2-like gene signature (75).