IRF5 and systemic lupus erythematosus: This result was supported by Lyn being found to negatively regulate TLR-MyD88-IRF5-dependent expression of Type 1 IFNs in dendritic cells and by the double knock out of Lyn and IRF5 (Lyn−/− IRF5−/−) in mice ameliorating SLE-like pathology (117).