LGALS1 and cranioectodermal dysplasia: Overall, while control duodenal biopsies showed moderate Gal-1 staining, and both epithelium and stroma from untreated CeD patients were poorly labeled, CeD-GFD biopsies showed a dramatic increase in Gal-1 immunoreactivity (p < 0.001; Figure 2M), which correlated with normalization of duodenal mucosal structure.