To this end, we exploited a well-characterized mouse model for CD, i.e., SAMP1/YitFc (SAMP), in which the main pathology is a spontaneous ileitis that is strikingly similar to human CD, with skip lesions, transmural inflammation, and scarring that can lead to stricture formation (47, 48). The gene discussed is TMEM201; the disease is Cowden disease.