CD40LG and HIV-1 infection: It has also been observed that the IGHV1 (34.4%) and IGHV4 (26.15%) subgroups were the most dominant among naïve IgM libraries in human adults but that these representations could be altered during early (40 days) or advanced (8 months) HIV-1 infection with differences between IgM and IgG frequencies, as well as between peripheral blood mononuclear cells (PBMC) and bone marrow (BM) compartments (63).