Although we did not observe more MPs-DNA + and MPs-RNA + frequency in SLE patients, our results showed that PMPs-IC induce IFNs-I secretion, possible through the binding of FcγR and TLR on the plasma membrane and once internalized, these vesicles can exposure the nucleic acids that contain to interact with endosomal TLRs. Here, FCGR2A is linked to systemic lupus erythematosus.