It has been demonstrated that cells subjected to scratch wound increase cell proliferation (Lampugnani, 1999; Kornyei et al., 2000), whereas the cell proliferation positively correlates with CD73 expression in many different tumor cell lines, including glioma (Turnay et al., 1989; Christensen et al., 1996; Ciccarelli et al., 2000; Ohana et al., 2001; Bavaresco et al., 2008; Gao et al., 2017). Here, NT5E is linked to central nervous system cancer.