NT5E and cancer: Studies in a large number of human disorders demonstrate important role of CD73 in the immunity and cell communication (Schetinger et al., 2007; Deaglio and Robson, 2011; Ghiringhelli et al., 2012; Antonioli et al., 2013a,b; Gao et al., 2014) and highlight its potential as a pharmacologic target for immunomodulation and cancer treatment (Corbelini et al., 2015; Antonioli et al., 2016, 2017).