As shown in Figure 2B, depletion of tau in J20 mice failed to reverse APP-induced memory impairments when the same test paradigm as that described by Roberson et al. (2011) was used; likewise, tau depletion did not improve cognitive performance by J20 mice in a variation of the MWM in which the escape platform is submerged (Supplementary Figure 2). Here, APP is linked to memory impairment.