An abundance of evidence suggests that Aβ and tau AD pathology appear to mutually drive each other (Jack et al., 2013; Musiek and Holtzman, 2015) and that neuronal activation may increase either the aggregation, deposition and/or propagation of Aβ and tau (Bakker et al., 2012; Wu et al., 2016). Here, MAPT is linked to Alzheimer disease.