MC4R and Hyperinsulinemia: It is conceivable that during early weight loss, SDV alters the set point due to reversal (or normalization) of the underlying hyperinsulinemia in Mc4r−/− mice (Huszar et al., 1997; Ste Marie et al., 2000) as a result of denervation of the insulin-secreting cells of the pancreas, and presumably depletion of hepatic glycogen stores.