IGHE and Lymphadenopathy: There was a greater number of strongly cytoplasmic IgE-positive cells in the IgG4-related lymphadenopathy specimens than in the non-specific lymphoid hyperplasia specimens (mean: 3.83 ± 3.99 vs. 1.20 ± 1.79 cells per HPF, respectively; P = 0.007) (Fig. 2C).