This suggests that in melanoma cells TGFβ can trigger a switch from YAP/PAX3-driven transcription to SMAD/YAP/TEAD-driven transcription, an idea that is further supported by the fact that TGFβ suppresses PAX3 expression [31, 32], thus reducing the amount of PAX3 available for YAP binding. The gene discussed is TGFB1; the disease is melanoma.