Most intriguingly, however, when we focused on the high COL1A1 cohort and further stratified the data according to their differentiation and proliferation status by looking at TRPM1, TYRP1 and CDK4, the median survival was even lower and dropped below 50 months (Fig. 7i), clearly emphasizing that the differentiation state of melanomas could act as prognostic factor. This evidence concerns the gene CDK4 and melanoma.