Most importantly, histological analysis revealed that while AKT/Yap/pT3 tumors consisted of pure ICC, as also indicated by strong immunoreactivity for the CK19 biliary marker (Fig. 3d,f), AKT/Yap/dnRBPJ liver tumors consisted mostly of hepatocellular adenomas and few HCC lesions. This evidence concerns the gene AKT1 and intrahepatic cholangiocarcinoma.