PTGS2 and Chronic Obstructive Asthma: Among the most significant associations is a novel association between the gene PTGS2 (Prostaglandin-Endoperoxide Synthase 2) and ICD-9 493.20 (chronic obstructive asthma) with P-value = 4.90e − 08 and also between the gene ADRA1D and ICD9-9 780.93 (memory loss) with P-value = 7.64e − 07, where the gene ADRA1D is already known to be associated with Schizophrenia47.