ADRA2B and major depressive disorder: We found an association between ADRA2B and “substance addiction and disorders” (ICD-9 305.00; lowest P-value = 3.88e − 10; beta = 4.51; functional annotation filter 2), the drugs known to target this gene include Amoxipine, Amphetamine, Loxapine, Clozapine, and the drugs are prescribed for are depression, stress and attention deficit hyperactivity disorder (ADHD).