For example, the top result from the diagnosis codes analysis observed in the functional annotation filter category 2 was an association between the calcium-sensing receptor gene (CASR) and the diagnosis of “hypercalcemia” (ICD-9 275.42, P-value = 1.34e − 22, beta = 3.89, functional annotation filter 2), Supplemental Table 1. The gene discussed is CASR; the disease is Hypercalcemia.