We found an association between ADRA2B and “substance addiction and disorders” (ICD-9 305.00; lowest P-value = 3.88e − 10; beta = 4.51; functional annotation filter 2), the drugs known to target this gene include Amoxipine, Amphetamine, Loxapine, Clozapine, and the drugs are prescribed for are depression, stress and attention deficit hyperactivity disorder (ADHD). The gene discussed is ADRA2B; the disease is depressive symptom measurement.