TGFB2 and mandibuloacral dysplasia with type A lipodystrophy: Consistent with this observation, it has been reported that osteoblast-like cells and serum samples from MADA patients (which accumulate prelamin A) show an increase in TGFβ−2 secretion32,33.These factors showed upregulation in the secretome from preA-adipocytes as well, although the fold of induction was much lower in most cases.