To study AβO-targeting of synapses in human brain, we used tissue samples from three neuropathologically confirmed AD brains and three non-demented control brains, evaluating a total of 15 plaques and >10,000 synapses in AD samples and >20,000 synapses in control samples (for detailed case information and numbers, refer to Table 2). Here, ABO is linked to Alzheimer disease.