GRN and Alzheimer disease: Therefore, this may imply that CSF1R, in concert with TREM2, TYROBP, and GRN, plays a key role in Aβ plaque removal, hypothesis supported by previous literature, reporting CSF1R overexpressed in AD patients particularly around senile plaques and taking part in Aβ removal (Akiyama et al., 1994) (Murphy et al., 2000) (Mizuno et al., 2011) (Boissonneault et al., 2009).