On the other hand, motor features like ataxia and spasticity may appear in the course of AD progression, particularly in the cases caused by or associated to PSEN1 mutations (Rossor et al., 2010) and AD patients may display MRI patterns and neuropathological features typical of adult-onset leukodystrophies (Smith et al., 2000, Marnane et al., 2016, Barber et al., 1999, Guerreiro et al., 2013), suggesting a potential common pathogenic ground. Here, PSEN1 is linked to Alzheimer disease.