PSEN1 and Alzheimer disease: We do not report any significant differential expression in Arsa, Csf1r, Eif2b1, Eif2b2, Eif2b3, Eif2b4, Eif2b5, Htra1, Notch3, and Trex1 until the development of severe AD pathology, markedly pronounced in the most aggressive AD strain studied, HOTASTPM, homozygous for the Swedish mutation APP p.K670N/M671L and PSEN1 p.M146V, 8 months of age (Fig. 2A–D, Supplementary Tables S3 and S4).