In 10 COPD patients whose blood samples were collected again after 1-year treatment, intracellular FPR3 expressions of M1 monocyte (6.5 ± 2.6 vs. 2.9 ± 0.7 MFI, p = 0.002, Fig. 3a), NK cell (2.6 ± 0.6 vs. 2.0 ± 0.3 MFI, p = 0.014, Fig. 3b) and helper T cell (2.7 ± 0.8 vs. 1.9 ± 0.4 MFI, p = 0.031, Fig. 3c) all showed significant elevation. This evidence concerns the gene FPR3 and chronic obstructive pulmonary disease.