Although we acknowledge that the biological and clinical relevance of these findings needs further support by larger studies, our findings indicate that COPD patients are characterized by decreased FPR2/FPR3 expressions and defective ANXA1 generation associated with decreased M2a percentage in the blood immune cells, and a higher moderate exacerbation risk is associated with both decreased FPR2 expression on neutrophil and decreased serum ANXA1 levels. The gene discussed is FPR3; the disease is chronic obstructive pulmonary disease.