ANXA1 and chronic obstructive pulmonary disease: Serum ANXA1 levels was lower in the 40 COPD patients as compared with that in the 16 healthy non-smokers (1.5 ± 1.8 vs. 3 ± 1.9 ng/ml, adjusted p = 0.007, Fig. 4a), while serum SAA, LL-37, LXA4, and RvD1 levels were not different between the case and control groups.