Blood M2a monocyte percentage in the total CD14+ monocytes (2.8 ± 4.1 vs. 11.2 ± 13.4%, adjusted p = 0.006, Fig. 1a) was significantly decreased, and percentages of NK (10.5 ± 8.8 vs. 1.6 ± 1.2%, adjusted p = 0.001, Fig. 1b)/NK T (2.8 ± 2.9 vs. 0.2 ± 0.1%, adjusted p = 0.005, Fig. 2c)/Th (27.8 ± 13.1 vs. 9.7 ± 13.2%, adjusted p < 0.001, Fig. 1d)/Tc (16.6 ± 10.6 vs. 6.3 ± 8.5%, adjusted p = 0.001, Fig. 1e) cells in the total lymphocytes was significantly increased in the COPD patients as compared with that in the healthy non-smokers. The gene discussed is CD14; the disease is chronic obstructive pulmonary disease.