Intracellular FPR3 expressions of M1 monocyte (4.1 ± 2.5 vs. 7.3 ± 2.5 MFI, adjusted p < 0.001, Fig. 2a) and M2a monocyte (7.7 ± 5.4 vs. 11.3 ± 5 MFI, adjusted p = 0.042, Fig. 2b) were both significantly lower in the COPD patients as compared with that in the healthy non-smokers. The gene discussed is FPR3; the disease is chronic obstructive pulmonary disease.