Stepwise logistic regression analysis showed that intracellular FPR3 expression of NK cell (OR 0.101, 95% CI 0.013–0.778, p = 0.028) and Th cell percentage (OR 1.096, 95% CI 1.013–1.185, p = 0.022) were independently associated with COPD at presentation after adjusting for age and co-morbidity. The gene discussed is FPR3; the disease is chronic obstructive pulmonary disease.