PRKCG and peripheral nerve injury: It has been well established that robust spinal activation of glial cells, microglia, and astrocytes, in particular, are essential for the development of chronic mechanical allodynia after peripheral nerve injuries, through central sensitization of neural circuits in SC-DHs specific for chronic mechanical allodynia, such as aberrant activation of PKCγ+ excitatory interneurons in the inner lamina II [3–5, 8–10].