MYLK and Vascular dilatation: Finally, our finding of a missense mutation of the MYLK gene in a large consanguineous family with aneurysmal disease may provide an excellent opportunity to conduct a long-term prospective study to determine the disease early signs and to clarify the contribution of new genetic markers such like the microRNAs (e.g miR-195 and miR-29b) [19] to the family disease in homozygous and heterozygous carriers and non-carriers of the mutation as part of a prediction and prevention strategy for this family.