IL6 and systemic inflammatory response syndrome: Sepsis episodes were more likely to occur in patients with higher PIM-II score (p = 0.034), longer duration of PICU stay until onset of disease (p <  0.001), previous history of SIRS and/or sepsis (p <  0.001), and were associated with higher levels of PTT (p = 0.013), d-dimers (p = 0.001), fibrinogen (p = 0.018), IL-6 (p = 0.001), PCT (p = 0.020), CRP (p = 0.009), body temperature (p <  0.001) and lower levels of platelets (p = 0.023).