The AA genotype frequency of ERCC2-rs1799793 polymorphism revealed an association with high risk of breast cancer in both homozygote and recessive models (AA vs. GG, odds ratio (OR): 2.66, 95% confidence interval (CI): 1.20–5.91, p = 0.016; AA vs. GG + GA, OR: 2.90, 95% CI: 1.34–6.26, p = 0.0069), respectively. Here, ERCC2 is linked to breast carcinoma.