A total of 156 controls and 151 BC subjects were successfully genotyped for the following selected SNPs: ERCC2-rs1799793 (G934A), ERCC2-rs13181 (A2251C), MTHFR-rs1801133 (C677T) and MTHFR-rs1801131 (A1298C). The gene discussed is ERCC2; the disease is breast cancer.