ERVW-1 and arthritic joint disease: An arginine or a lysine residue is also found in the TMD of the envelope protein of most other lentiviruses, notably HIV-2, simian (SIV) and bovine (BIV) immunodeficiency viruses, caprine arthritis/encephalitis virus (CAEV), Maedi visna ovine pneumonia virus (MVV) and equine infectious anemia virus (EIAV) (Fig. 1).